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Cautions
Your doctor should check your progress at regular visits, especially during the first few months of treatment with this medicine. The amount of Zyban you take may have to be changed often to meet the
needs of your condition and to help avoid unwanted effects.
Do not take Zyban within 14 days of taking an MAO inhibitor.
Zyban is sold under different brand names for different uses.
If you are already taking medicine for mental depression or to help you stop smoking, discuss this with your health care professional before taking Zyban. It is very important that you receive only o
ne prescription for Zyban at a time.
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Before Taking This Medicine
Zyban has not been tested in pregnant women. If you are pregnant or plan to become pregnant, do your best to quit smoking with the aid of counseling and support before turning to drug therapy. For the
sake of the baby, you should avoid smoking or taking nicotine in any other form while pregnant.
Zyban appears in breast milk and could affect a nursing infant. Ask your doctor whether it wi
ll be better to discontinue the medication or to stop breastfeeding.
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How should this medicine be used?
Treatment with this drug begins while you are still smoking. Zyban needs about a week to reach an effective level in your body; so to improve your chance of success, you should not attempt to quit unt
il the second week of treatment. Set a firm date for quitting. If you are still smoking after that date, your odds of breaking the habit will be worse. You should keep taking Zyban for 7 to 12 weeks.
You can use nicotine patches along with Zyban. However, combining the two treatments can raise your blood pressure, so it's important to tell your doctor if you plan to use both. Do not smok
e while using a patch, because too much nicotine can cause serious side effects.
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What Is It
Zyban was introduced in the USA in 1985 and was withdrawn in 1986 because of an unacceptable incidence of seizures. In 1989 it was reintroduced in the USA (maximum dose of 450 mg daily). Zyban was fir
st approved in Canada in 1998 as an SR twice-daily formulation. In one RCT buproprion SR, 150 mg daily and 150 mg BID, were similar and more effective than placebo based on physician rated scores of d
epression at 8 weeks.8 In 2 RCTs Zyban (150-400 mg/day) was similar in effectiveness to sertraline (50-200 mg/day) at 8 weeks, but the incidence of satisfaction with sexual functioning was less with s
ertraline (63%) than buproprion (79%) and placebo (78%). 9, 10
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Other Medicines
When you are taking Zyban, it is especially important that your health care professional know if you are taking any of the following:
- Tricyclic antidepressants (amitriptyline [e.g., Elavil
], amoxapine [e.g., Asendin], clomipramine [e.g., Anafranil], desipramine [e.g., Pertofrane], doxepin [e.g., Sinequan], imipramine [e.g., Tofranil], nortriptyline [e.g., Aventyl], protriptyline [e.g.,
Vivactil], trimipramine [e.g., Surmontil]) or
-
- Monoamine oxidase (MAO) inhibitor activity (isocarboxazid [e.g., Marplan], phenelzine [e.g., Nardil], procarbazine [e.g., Matulane], selegi
line [e.g., Eldepryl], tranylcypromine [e.g., Parnate])¡X Do not take Zyban while you are taking or within 14 days of taking an MAO inhibitor
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Overdose
It is especially important to check with your doctor before combining Zyban with the following:
- Alcohol
- Amantadine (Symmetrel)
- Antidepressants such as Norpramin, Pamelor, Pa
xil, Prozac, Tofranil, and Zoloft
- Beta blockers (heart and blood pressure medications) such as Inderal, Lopressor, and Tenormin
- Carbamazepine (Tegretol)
- Cimetidine (Tagamet)
- Cyclophosphamide (Cytoxan)
- Heart-stabilizing drugs such as Rythmol and Tambocor
- Levodopa (Dopar, Larodopa, Sinemet)
- Major tranquilizers such as Haldol, Risperdal and Thorazine <
br> - MAO inhibitors such as the antidepressants Nardil and Parnate
- Orphenadrine (Norflex)
- Phenobarbital
- Phenytoin (Dilantin)
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