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Significant Interactions:
When you are taking cyclobenzaprine, it is especially important that your health care professional know if you are taking any of the following:

- Alcohol or
- Central nervous system (C NS) depressants (medicines that cause drowsiness) or
- Tricyclic antidepressants (amitriptyline [e.g., Elavil], amoxapine [e.g., Asendin], clomipramine [e.g., Anafranil], desipramine [e.g., Perto frane], doxepin [e.g., Sinequan], imipramine [e.g., Tofranil], nortriptyline [e.g., Aventyl], protriptyline [e.g., Vivactil], trimipramine [e.g., Surmontil])¡XThe chance of side effects may be increas d

Overdose
Symptoms of Flexeril overdose may include:
- Agitation, coma, confusion, congestive heart failure, convulsions, dilated pupils, disturbed concentration, drowsiness, hallucinations, high or low te mperature, increased heartbeats, irregular heart rhythms, muscle stiffness, overactive reflexes, severe low blood pressure, stupor, vomiting

High doses also may cause any of the conditions li sted in "What Side Effects May Occur?"

What Is It
Flexeril - Cyclobenzaprine (sye-kloe-BEN-za-preen) is used to help relax certain muscles in your body. It helps relieve the pain, stiffness, and discomfort caused by strains, sprains, or injuries to y our muscles. However, this medicine does not take the place of rest, exercise or physical therapy, or other treatment that your doctor may recommend for your medical problem. Cyclobenzaprine acts on t he central nervous system (CNS) to produce its muscle relaxant effects. Its actions on the CNS may also cause some of this medicine's side effects.

How should this medicine be used?
Flexeril may be taken with or without food.

Flexeril should be used only for short periods (no more than 3 weeks). Since the type of injury that Flexeril treats should improve in a few weeks, there is no reason to use it for a longer period.

Flexeril may cause dry mouth. Sucking a hard candy, chewing gum, or melting ice chips in your mouth can provide temporary relief.

Cautions
Cyclobenzaprine may cause dryness of the mouth. For temporary relief, use sugarless candy or gum, melt bits of ice in your mouth, or use a saliva substitute. However, if your mouth continues to feel d ry for more than 2 weeks, check with your medical doctor or dentist. Continuing dryness of the mouth may increase the chance of dental disease, including tooth decay, gum disease, and fungus infection s

Other medical problems
The presence of other medical problems may affect the use of cyclobenzaprine. Make sure you tell your doctor if you have any other medical problems, especially:
- Glaucoma or
- Problems with urination¡XCyclobenzaprine can make your condition worse
- Heart or blood vessel disease or
- Overactive thyroid¡XThe chance of side effects may be increased




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